Renew Health Centers
Treatment Resistant Depression in San Antonio
What Happens during Treatment Resistant Depression in San Antonio?
If you have tried multiple medications and still feel stuck in depression, you are not alone. Treatment Resistant Depression (TRD) affects millions — and requires a different approach. At Renew Health Center in San Antonio, we offer advanced care for patients who have not found relief through typical treatments. Our team focuses on identifying what is holding your recovery back, and then work toward real solutions that fit your life.
Who Should Seek Care for Treatment Resistant Depression in San Antonio?
When you have already tried two or more antidepressants with little or no improvement, you may have TRD. But that is not the only indicator. We encourage patients to reach out if they:
- Still struggle with depression despite medication
- Experience intolerable side effects that make adherence hard
- Have co-occurring anxiety, PTSD, or chronic pain
- Feel emotionally flat or disconnected even after “some” improvement
- Have not had a full psychiatric evaluation
Even if past care didn’t help, that doesn’t mean you’re out of options.

What Options Are Available for Treatment Resistant Depression at Renew Health Center San Antonio?
Comprehensive Diagnostic Review
We reassess your full medical and psychiatric history, current medications, and past treatment responses. This often reveals patterns or missed factors that guide a better plan.
Medication Adjustment
Our team explores options like switching drug classes, adding mood stabilizers, or incorporating atypical antipsychotics — all with close monitoring and regular follow-up.
Esketamine (SPRAVATO®) Therapy
FDA-approved for TRD, SPRAVATO® is a nasal spray derived from ketamine. It's used under supervision in our clinic and may offer fast relief where others have not.
Coordination with Psychotherapy
We screen for and manage related conditions like thyroid disorders, chronic fatigue, or substance use, which can impact depression treatment outcomes.
Whole-Person Support
We screen for and manage related conditions like thyroid disorders, chronic fatigue, or substance use, which can impact depression treatment outcomes.
Why Choose Renew Health Center for Treatment Resistant Depression in San Antonio?
TRD patients need care that’s flexible, responsive, and built on trust. We offer:
Providers trained in complex mood disorder management
In-clinic administration of SPRAVATO® for qualified patients
Strong coordination between primary care, psychiatry, and therapy
Help navigating prior authorizations and insurance hurdles
If you are still struggling after multiple treatments, you deserve a different approach. Let’s explore what else might work — and how we can support you through it.
Call us today at 210-761-9001

FAQ's
You Can Find All Answers Here
If you have tried two or more antidepressants from different classes, at adequate doses and duration, without significant improvement — that may indicate TRD. A formal diagnosis requires evaluation by a healthcare provider.
SPRAVATO® (esketamine) is a nasal spray medication derived from ketamine, approved for TRD. It works differently from typical antidepressants, targeting NMDA receptors to rapidly improve symptoms. It's administered under supervision in a clinical setting.
Most insurance plans offer some coverage for SPRAVATO® when certain criteria are met. Our staff helps patients with pre-authorization and paperwork.
Often, yes. We may adjust your current regimen, add an augmenting agent, or incorporate a new option like esketamine without restarting everything. Your care is always tailored to what has (and hasn’t) worked for you.
While every case is different, options like SPRAVATO® may offer relief within hours or days. Other changes, like medication switches, may take several weeks. The key is consistent follow-up and willingness to adapt the plan if needed.